Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...) cleaving enzyme . In mice, AbetaPP and SP1 mRNA and their protein products were elevated late in life; Abeta levels declined in old age. In monkeys, SP1, AbetaPP, and BACE1 mRNA declined in old age, while protein products and Abeta levels rose. Proteolytic processing in both species did not match production of Abeta. In primates, AbetaPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Abeta levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. (shrink)

The Arabic philosophical fable _Hayy Ibn Yaqzan _is a classic of medieval Islamic philosophy. Ibn Tufayl, the Andalusian philosopher, tells of a child raised by a doe on an equatorial island who grows up to discover the truth about the world and his own place in it, unaided—but also unimpeded—by society, language, or tradition. Hayy’s discoveries about God, nature, and man challenge the values of the culture in which the tale was written as well as those of every contemporary society. (...) Goodman’s commentary places _Hayy Ibn Yaqzan _in its historical and philosophical context. The volume features a new preface and index, and an updated bibliography. “One of the most remarkable books of the Middle Ages.”—_Times Literary Supplement_ “An enchanting and puzzling story.... The book transcends all historical and cultural environments to settle upon the questions of human life that perpetually intrigue men.”—_Middle East__ Journal_ “Goodman has done a service to the modern English reader by providing a readable translation of a philosophically significant allegory.”—_Philosophy East and West_ “Add[s] bright new pieces to an Islamic mosaic whose general shape is already known.”—_American Historical Review_. (shrink)

The Exalted Fath: Ha-Emunah ha-Ramah Transleted by Solomon Ibn Lavi, Ha-Emunah ha-Nissaʼah Transleted by Samuel Ibn Matut, The Anonymous Commentary to HaEmunah ha-Ramah.

Freethought and atheism in classical Islam -- Arabic philosophy and its influence on Western freethought -- The treatise of the three impostors : Moses, Jesus, and Muhammad, and its origins in Islam -- Averroes and Ibn Tufayl, and their influence on Western freethought -- Atheism, freethought and Islam in the 19th, 20th, and 21st Century -- Conclusion : The Allah that failed.

Solomon Ibn Gabirol The Fountain of Life (Fons Vitae) TRANSLATED BY Harry E. Wedeck WITH AN INTRODUCTION BY Theodore ...

Solomon Ibn Gabirol The Fountain of Life (Fons Vitae) TRANSLATED BY Harry E. Wedeck WITH AN INTRODUCTION BY Theodore E. James L ...

A translation of the Fons vitae of Solomon ibn Gabirol (born 1021/1022), who was the first Jewish philosopher in Spain. In the Fons vitae, Gabirol argues that there is a sensible and an intelligible world. These doctrines profoundly influenced medieval Christian thinkers. Because of the Fons vitae, Gabirol is today widely recognized as one of the greatest Jewish Neoplatonists.

... as the source of life for the intellectually oriented Jews of the Western world. As such it suffered almost complete sterility right from the start. ...